Researchers are developing a shield for medicines to be able to reach the intended targets without being assaulted on the way by your own body.
As superbugs become increasingly dangerous to human health, NC State researchers have developed a soft material that preserves medicines capable of treating infections without the risk of antimicrobial resistance.
With his colleague Christopher Gorman in the Department of Chemistry and students Ryan Smith and Juliana O’Brien, Stefano Menegatti, a University Faculty Scholar and an associate professor of chemical and biomolecular engineering, developed new dendrimers — highly structured macromolecules — that act as a glue around nanoparticle templates. Such templates include bacteriophages, which are viruses that can infect and attack harmful bacteria in the body. While they can be an alternative to traditional antibiotics, they can be difficult to formulate and stabilize as a medicine. To remain safe and effective, therapeutic bacteriophages need to be protected from environmental changes.