A fruit fly gene called “Clueless” could become the best current hope for a cure for Parkinson’s disease.
‘Clueless’ Gene in Fruit Flies May Lead to New Parkinson’s Treatments
From parkinsonsnewstoday.com
2022-04-04 13:35:47
Excerpt:
Over-expressing a fly gene called clueless (clu) can lessen mitochondrial defects in fruit fly models of Parkinson’s disease, a new study reveals.
The results also showed that CLUH, the human equivalent of the fly clueless gene, has a similar function, which may pave the way toward new treatment approaches for Parkinson’s.
“When we modified [clu] in flies, symptoms analogous to Parkinson’s disease improved substantially,” Ming Guo, MD, PhD, a professor at UCLA and co-author of the study, said in a press release.
The study, “Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria,” was published in Nature Communications.
